Article published in the journal Trials

Eleonora Carrozzo has co-authored a new article published in the journal Trials on methodological challenges in two-period randomised crossover trials for behavioural interventions.

The paper focuses on situations where treatment effects persist after the intervention ends, meaning participants may not return to baseline. This has important implications for study design and statistical analysis, especially in context and digital health interventions.

Here the reference:

Kulnik ST, Carrozzo AE, Crutzen R. Persistent carry-over in a two-period randomised crossover design for behavioural interventions without the expectation of return to baseline after intervention cessation. Trials. 2025 Dec 4;26(1):561. doi: 10.1186/s13063-025-09358-9. PMID: 41345689; PMCID: PMC12676868.